The Integrative Neuromuscular Biology Laboratory is committed to consistent discussion around and implementation of equity, diversity and inclusion principles in and around our research, mentorship and learning. Please click here for more information on our lab’s EDI actions and viewpoints.
The focus of the research in the Integrative Neuromuscular Biology Laboratoy is to investigate molecular mechanisms of neuromuscular plasticity, with an emphasis on identifying new therapeutic strategies for neuromuscular disorders. The central experimental questions that form the foundation of our research program are:
To address these questions, we design investigations around lifestyle- and pharmacological-based strategies focused on the manipulation of powerful phenotype-bending molecules in the neuromuscular system. Furthermore, we employ an integrative and rigorous cell-to-animal experimental approach, as well as an innovative combination of molecular physiological solutions. A goal of our research is to decipher how interventions such as physical activity, experimental small molecules, and common generic medications can be used to slow, prevent, or reverse neuromuscular pathologies.
Undergraduate students interested in thesis, research practicum, or volunteer opportunities within the Integrative Neuromuscular Biology Lab (INBL) are invited to apply by sending an email to the following INBL MS Teams address:
3518f4f7.mcmaster.ca@amer.teams.ms
Applications are considered complete if the email contains responses that address the following:
Applications will be reviewed by Dr. Ljubicic and the INBL research team, who will contact applicants via email for interviews.
We especially welcome applications from First Nations, Métis and Inuit peoples, members of racialized communities (“visible minorities”), persons with disabilities, women, and persons who identify as 2SLGBTQ+
Professor; University Scholar
Neuromuscular plasticity refers to the remodeling of the neuromuscular system in response to genetic or environmental cues. Neuromuscular disorders, including the neuromuscular alterations that are hallmarks of advanced aging, are more common in Canada then generally appreciated. The central experimental questions that form the foundation of our research program are: 1) What roles do phenotype-modifying proteins play in the maintenance and remodeling of the peripheral neuromuscular system, and 2) Are these molecules efficacious therapeutic targets for neuromuscular disorders? To address these questions, we design investigations around rational lifestyle- and pharmacological-based strategies focused on the manipulation of powerful phenotype-bending molecules in the neuromuscular system. Furthermore, we employ an integrative and rigorous cell-to-animal experimental approach, as well as an innovative combination of molecular physiological solutions. The long-term goal of our research is to expand fundamental understanding of the mechanisms governing neuromuscular plasticity, as well as to identify novel, evidence-based therapeutic strategies to improve the lives of those with compromised neuromuscular systems.
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